Academic Qualifications

Doctor of Philosophy (PhD):In Biology in 2006

Institution : Kobe University, Kobe, Japan

Master of Science (Thesis group) : In Biochemistry and Molecular Biology in 1996

Institution : Dhaka University, Dhaka, Bangladesh

Secured result : First class first position

Bachelor of Science (Honors) : In Biochemistry and Molecular Biology in 1995

Institution : Dhaka University, Dhaka, Bangladesh

Secured result : First class fourth position

Higher Secondary Certificate : In Higher Science in 1991

(Science group) (Physics, Chemistry, Mathematics & Biology)

Institution : Patuakhali Govt. Univ. College, Patuakhali, Bangladesh

Secured result : First division

Secondary School Certificate : In Basic Science in 1989

(Science group) (General science, General and Higher Mathematics)

Institution : B.S. High School, Patuakhali, Bangladesh

Secured result : First division

Academic Positions

Present:

1. Treasurer (08.10.2015-Present)

University of Barisal, Barisal-8200, Bangladesh

Previous

2. Professor (10.10.2013-Present)

Department of Biochemistry and Molecular Biology

University of Dhaka, Dhaka-1000, Bangladesh

3. Associate Professor (26.05.2011-09.10.2013)

Department of Biochemistry and Molecular Biology

University of Dhaka, Dhaka-1000, Bangladesh

4. Assistant Professor (29.11.2006 – 01.06.2008; 01.04.2011-25.06.2011)

Department of Biochemistry and Molecular Biology

University of Dhaka, Dhaka-1000, Bangladesh

5. Assistant Professor (01.04.2010 – 31.03.2011)

Department of Molecular Sciences, Faculty of Life Science

Kyoto Sangyo University, Japan

6. Visiting Associate Professor (01.06.2008 – 31.03.2010)

Research Center for Environmental Genomics

Kobe University, Japan

7. Lecturer (01.03.2001 – 28.11.2006)

Department of Biochemistry and Molecular Biology,

University of Dhaka, Bangladesh

8. Research officer (14.03.2000 – 13.02.2001)

Molecular Genetics Laboratory,

International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B)

Research

Ph.D. research:

How the frogs (Xenopus laevis) egg membrane-raft associated molecules uroplakin III (xUPIII) and uroplakin Ib (xUPIb) transmit the sperm mediated signal to the cytosolic molecules like xSrc, a tyrosine kinase was revealed. At fertilization the oncogenic product Src activates within a minute and phosphorylates xUPIII, a single transmembrane protein. The digestion of xUPIII by sperm protease and the activation of xSrc are correlated. The tetraspanin xUPIb, a binding partner of xUPIII cooperatively regulate xSrc.

(This research was carried out in the Dept. of Biosystems Science, Kobe University, Japan.)

Post-doctoral research:

The function of Xenopus G protein subunits on xSrc activity was tested using HEK293 culture cells. The xGiα and xGqα up regulate the xSrc activity whereas xGγ2β1 show the little effect. The inhibitory effect exert by xUPIb/xUPIII complex is rescued by either xGiα or xGqα subunit but not by xGγ2β1.

(This research was carried out in Kobe University and Kyoto Sangyo University, Japan.)

M.Sc. research:

The mosquito larvicidal activity of several Bacillus sphaericus species and Bacillus thuringiensis using their spores and crude extracts were compared. A mosquito larvicidal toxic protein was purified.

(This research was carried out in Dhaka University, Bangladesh.)

Other research:

Study the diarrheal potency of several Vibrio cholera strains which contain the different forms of CTXΦ using adult rabbit diarrhea model. CTXΦ is a filamentous bacteriophage which encodes cholera toxin.

(This research was carried out at the International Centre for Diarrhoeal Disease Research, Bangladesh.)

Publications

Peer reviewed research:

1. Amin, MA, Islam, MB, AKM Mahbub Hasan, Chowdhury, EK and Shekhar, HU. 2015. Pattern of Drug Resistance of Pathogenic Microbes in the Street Foods of Dhaka City, Bangladesh. Biores Comm. 1(1), 48-52.

2. AKM Mahbub Hasan, Hashimoto A, Maekawa Y, Matsumoto T, Kushima S, et al. 2014. The egg membrane microdomain-associated uroplakin III-Src system becomes functional during oocyte maturation and is required for bidirectional gamete signaling at fertilization in Xenopus laevis. Development 141: 1705-1714.

3. Hoque MA, Khatun MA, Islam R, Shekhar HU, Haque ME, AKM Mahbub Hasan. 2014. Antibacterial Activity of the Organic Extracts of Stem Bark of Cinnamomum aromaticum Nees. Dhaka Univ J Pharm Sci 13(2):221-224.

4. Sakib MS, Islam MR, AKM Mahbub Hasan, Nabi AHMN. 2014. Prediction of Epitope-Based Peptides for the Utility of Vaccine Development from Fusion and Glycoprotein of Nipah Virus Using In Silico Approach. Advances in Bioinformatics 2014: 17.

5. Yesmin N, Elias SM, Rahman MS, Haque T, AKM Mahbub Hasan, et al. 2014. Unique Genotypic Differences Discovered among Indigenous Bangladeshi Rice Landraces. International Journal of Genomics 2014: 11.

6. AKM Mahbub Hasan, ZH Mohammad, Hossain Uddin Shekhar. 2013. Lipid profile and renal function status in patients with hypothyroidism. J Bang Soc Pharm Professionals. 2 (II): 36-47

7. Kihira S, Yoshida J, Kawada Y, Hitomi Y, Asada T, Hisatomi R, Ohta A, Iwasaki T, AKM Mahbub Hasan, Fukami Y, Sato K. 2012. Membrane microdomain-associated uroplakin IIIa contributes to Src-dependent mechanisms of anti-apoptotic proliferation in human bladder carcinoma cells. Biol Open 1(10):1024-1034.

8. Uddin MM, Akteruzzaman S, Rahman T, AKM Mahbub Hasan, Shekhar HU. 2012. Pattern of beta-Thalassemia and Other Haemoglobinopathies: A Cross-Sectional Study in Bangladesh. ISRN Hematol 2012:659191.

9. Shibib BA, Amin MA, AKM Mahbub Hasan, Rahman R. 2012. A creeper, Coccinia indica, has anti-hyperglycaemic and anti-ureogenic effects in diabetic rats. J Pak Med Assoc 62(11):1145-1148.

10. Dipankar Das Gupta, Md. Enamul Haque, Md. Nahidul Islam, Shafiqur Rahman, AKM Mahbub Hasan and Baigid Alam Shibib. 2011. Alkaloid and Steroid from the Stem Bark of Jatropha curcas (Euphorbiaceae). Dhaka Univ. J. Pharm. Sci. 10 (1): 9-11.

11. Sabrina M. Elias, AKM Mahbub Hasan and Zeba I. Seraj. 2011. Microsatellite marker diversity and sequence polymorphism in the red gene locus of indigenous rice populations of Bangladesh. Plant Syst Evol. 296 (3-4):157-165.

12. Kushima S, Mammadova G, AKM Mahbub Hasan, Fukami Y, Sato K. 2011. Characterization of lipovitellin 2 as a tyrosine-phosphorylated protein in oocytes, eggs and early embryos of Xenopus laevis. Zoolog Sci. 28(8): 550-559.

13. Laisa A. Lisa, Sabrina M. Elias, M. Sazzadur Rahman, Saima Shahid, Tetsushi Iwasaki, AKM Mahbub Hasan, Keiko Kosuge, Yasuo Fukami, and Zeba I. Seraj. 2011. Physiology and gene expression of the rice landrace Horkuch under salt stress. Funct Plant Biol. 38 (4):282–292.

14. Lahiry G, Rahman T, AKM Mahbub Hasan, Dutta AK, Arif M, Howlader ZH. 2011. Assessment of Impact on Health of Children Working in the Garbage Dumping Site in Dhaka, Bangladesh. J Trop Pediatr. 57(6):472-5.

15. Ferdaus MZ, AKM Mahbub Hasan, Shekhar HU. 2010. Analysis of serum lipid profiles, metal ions and thyroid hormones levels abnormalities in beta-thalassaemic children of Bangladesh. J Pak Med Assoc. 60 (5):360-4.

16. M Jakir H Howlader, M Arif, Ahmad F Karim, M Rakibul Islam and AKM Mahbub Hasan. 2008. Oxidative Stress and Antioxidant Status in Thyroid Dysfunction. Bangladesh J of Med Sci. 14 (1):52-6.

17. AKM Mahbub Hasan, Ou Z, Sakakibara K, Hirahara S, Iwasaki T, Sato K, Fukami Y. 2007. Characterization of Xenopus egg membrane microdomains containing uroplakin Ib/III complex: roles of their molecular interactions for subcellular localization and signal transduction. Genes Cells.12 (2):251-67.

18. AKM Mahbub Hasan, Sato K, Sakakibara K, Ou Z, Iwasaki T, Ueda Y, Fukami Y. 2005. Uroplakin III, a novel Src substrate in Xenopus egg rafts, is a target for sperm protease essential for fertilization. Dev Biol. 286 (2): 483-92.

19. Sakakibara K, Sato K, Yoshino K, Oshiro N, Hirahara S, AKM Mahbub Hasan, Iwasaki T, Ueda Y, Iwao Y, Yonezawa K, Fukami Y. 2005. Molecular identification and characterization of Xenopus egg uroplakin III, an egg raft-associated transmembrane protein that is tyrosine-phosphorylated upon fertilization. J Biol Chem. 280 (15): 15029-37.

20. Faruque SM, Rahman MM, AKM Mahbub Hasan, Nair GB, Mekalanos JJ, Sack DA. 2001. Diminished diarrheal response to Vibrio cholerae strains carrying the replicative form of the CTX(Φ) genome instead of CTX(Φ) lysogens in adult rabbits. Infect Immun. 69 (10): 6084-90.

21. AKM Mahbub Hasan, Jahangir M, Rahim KA, Rahman M. 2000. Comparative study of mosquito larvicidal activity of locally isolated Bacillus sphaericus strains and commercially available ones. Bangladesh J Biochem 6: 69-74.

Review

22. AKM Mahbub Hasan, Ijiri T, Sato K. 2012. Involvement of Src in the Adaptation of Cancer Cells under Microenvironmental Stresses. J Signal Transduct 2012:483796.

23. Ijiri TW, AKM Mahbub Hasan, Sato K. 2012. Protein-tyrosine kinase signaling in the biological functions associated with sperm. J Signal Transduct 2012:181560.

24. AKM Mahbub Hasan, Fukami Y, Sato K. 2011. Gamete membrane microdomains and their associated molecules in fertilization signaling. Mol Reprod Dev. 78 (10-11):814-30.

Chapter

25. Sato KI, AKM Mahbub Hasan, Ijiri T. 2014. Focused Proteomics on Egg Membrane Microdomains to Elucidate the Cellular and Molecular Mechanisms of Fertilization in the African Clawed Frog Xenopus laevis. In: Sawada H, Inoue N, Iwano M, editors. Sexual Reproduction in Animals and Plants: Springer Japan. pp 157-170.

26. AKM Mahbub Hasan, Chakrobarty, S., Chakrobarty, R., Nabi, A.H.M. Nurun. 2014. Application of Biotechnology and Bioinformatics in Drug Designing and Discovery. In: Devarajan Thangadurai, Sangeetha J, editors. BIOTECHNOLOGY AND BIOINFORMATICS New Jersey, USA: Apple Academic Press. pp. 355-390.

27. AKM Mahbub Hasan, Takashi Matsumoto, Shigeru Kihira, Junpei Yoshida and Ken-ichi Sato. 2012. Phospho-Signaling at Oocyte Maturation and Fertilization: Set Up for Embryogenesis and Beyond Part I. Protein Kinases. Embryogenesis, p.447-498. Dr. Ken-Ichi Sato (Ed.), ISBN: 978-953-51-0466-7, InTech.

28. AKM Mahbub Hasan, Takashi Matsumoto, Shigeru Kihira, Junpei Yoshida and Ken-ichi Sato. 2012. Phospho-Signaling at Oocyte Maturation and Fertilization: Set Up for Embryogenesis and Beyond Part II. Kinase Regulators and Substrates. Embryogenesis, p.499-554. Dr. Ken-Ichi Sato (Ed.), ISBN: 978-953-51-0466-7, InTech.